SGC-707

SKU: orb1225968

Description

SGC-707 is a potent, selective and cell-active allosteric inhibitor of PRMT3 (IC50=31 nM; Kd=53 nM); shows outstanding selectivity against 31 other methyltransferases and more than 250 non-epigenetic targets; active in cells, also bioavailable and suitable for animal studies.

Key Properties

• CAS Number: 1687736-54-4
• MW: 298.3397
• Purity: >98% (HPLC)
• Formula: C₁₆H₁₈N₄O₂
• SMILES: O=C(NCC(N1CCCC1)=O)NC2=CC3=C(C=NC=C3)C=C2
• Target: HMTase
• Solubility: 10 mM in DMSO

Bioactivity

• In Vivo:
  Animal model: Western-type diet-fed LDL (lipoprotein) receptor knockout mice. Dosage: 10 mg/kg. Administration: Intraperitoneal injection; 10 mg/kg; 3 times per week; 3 weeks. Result: Exhibited 50% lower liver triglyceride stores as well as 32% lower plasma triglyceride levels.
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• In Vitro:
  Cell Viability Assay Cell line: HEK293 and A549 cells. Concentration: 0-10 μM. Incubation time: 6 hours. Result: Stabilized PRMT3 in both HEK293 and A549 cells with EC50 values of 1.3 μM and 1.6 μM, respectively.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SGC 707 | SGC707

Quick Database Links

Gene Symbol

HMTase