Sevelamer HCl

SKU: orb1226147

Description

Sevelamer HCl is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorption.

Key Properties

• CAS Number: 152751-57-0
• MW: 186.08
• Purity: >98% (HPLC)
• Formula: (C?H?N . C?H?ClO)x . x HCl
• SMILES: C=CCN.C1C(O1)CCl.Cl
• Solubility: DMSO:<1 mg/mL; Ethanol:<1 mg/mL; Water:<1 mg/mL

Bioactivity

• In Vivo:
  Sevelamer hydrochloride (1% mixed in diet; p.o. ; once daily for 5 weeks) reduces Npt2b-deficient mice serum phosphate levels, but fails to reduce the level in uremic WT mice. Sevelamer hydrochloride leads to a significant decrease in osteoclast number in uremic WT mice with a trend toward further decrease in Npt2b-/-mice. Sevelamer hydrochloride leads to a significant increase in Npt2b protein expression.
• In Vitro:
  Sevelamer hydrochloride (15 mg/mL; pH=6 or 8) decreases serum levels of gut-derived uremic toxins (such as IAA) or limits the elevation of gut-derived uremic toxins (initial concentration=1 μg/mL or 10 μg/mL).

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only