Sevelamer hydrochloride

SKU: orb1300849

Description

Sevelamer hydrochloride is a polymeric phosphate-binding agent used to treat hyperphosphatemia by inhibiting dietary phosphate absorption. It is widely applied in renal disease research, with studies demonstrating its efficacy in both in vitro binding assays and in vivo models of chronic kidney disease.

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 152751-57-0
• MW: 186.08
• Formula: (C₃H₇N·C₃H₅ClO·HCl)x
• SMILES: Cl.NCC=C.ClCC1CO1
• Target: Autophagy,FXR
• Solubility: DMSO:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vivo:
  Sevelamer is as effective as CaCO3 in reducing serum phosphorus, calcium-phosphorus product, and attenuating secondary hyperparathyroidism in nephrectomized rats (U) fed high phosphorus (HP) diet. Sevelamer results in markedly lower calcium deposition in the myocardium and aorta compared to control rats. Sevelamer suppresses calcification of the aorta media, and also the osteoid volume, fibrosis volume, and porosity ratio of femurs in chronic renal failure rats. Sevelamer results in a significantly lower degree of atherosclerosis and vascular calcification in uremic mice when compared with uremic control mice. Sevelamer exerts an effect on both intima and media calcification in uremic mice. Sevelamer treatment controlled serum P independent of increases in serum Ca, thus reducing serum calcium-phosphate product and further deterioration of renal function, as indicated by the highest creatinine clearances in uremic rats. Sevelamer is as effective as CaCO3 in the control of high-P-induced SH, as shown by similar serum PTH levels, parathyroid (PT) gland weight, and markers of PT hyperplasia. Sevelamer causes a dramatic reduction of renal Ca deposition compared with both uremic + high-P diet (U-HP) and the U-HP+CaCO3 diet. Sevelamer hydrochloride results in a fall in urine pH, as well as an increase in urinary ammonium and calcium excretion consistent with an increase in net acid excretion in animal model.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Autophagy, inhibit, NR1H4, Inhibitor, FXR, Sevelamer, Sevelamer HCl, Sevelamer hydrochloride, Sevelamer Hydrochloride

Compound Identifiers

PubChem CID

159247