Senicapoc

• Catalog Number: orb1304118
• Category: Small Molecules
• Description: Senicapoc
• CAS Number: 289656-45-7
• Purity: 99.50%
• MW: 323.34
• SMILES: C(C(N)=O)(C1=CC=C(F)C=C1)(C2=CC=C(F)C=C2)C3=CC=CC=C3
• Formula: C₂₀H₁₅F₂NO
• Biological Activity: Senicapoc (ICA-17043) is a potent inhibitor of the Gardos channel and ameliorates RBC dehydration in the SAD mouse. Senicapoc blocked Ca2+-induced rubidium flux from human RBCs with an IC50 value of 11 ± 2 nM (CLT IC50 = 100 ± 12 nM) and inhibited RBC dehydration with an IC50 of 30 ± 20 nM. Senicapoc is in treatment of Sickle Cell Disease and Sickle Cell Anemia
• Note: For research use only
• Expiration Date: 12 months from date of receipt.