Senexin-A

SKU: orb1226434

Description

A selective inhibitor of CDK8 (IC50=0.28 uM) and CDK19; inhibits CDK8 and CDK19 ATP site binding with Kd50 of 0.83 uM and 0.31 uM, respectively; inhibits only p21-induced transcription but not other biological effects of p21, inhibits β-catenin-dependent transcription in HCT116 colon carcinoma cells; suppresses damage-induced tumor-promoting paracrine activities of tumor cells and normal fibroblasts and reverses the increase in tumor engraftment and serum mitogenic activity in mice pretreated with doxorubicin.

Key Properties

• CAS Number: 1366002-50-7
• MW: 274.32
• Purity: >98% (HPLC)
• Formula: C₁₇H₁₄N₄
• SMILES: N#CC1=CC2=C(NCCC3=CC=CC=C3)N=CN=C2C=C1
• Target: CDK
• Solubility: DMSO: ≥100 mg/mL

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Senexin A

Quick Database Links

Gene Symbol

CDK