Sematilide HCl

SKU: orb1223454

Description

Sematilide (CK-1752) is a class III antiarrhythmic. It is a selectively delayed rectifier K+ current (IKr) channel blocker. It inhibits rapidly activating Ik in guinea pig atrial myocytes, resulting in the prolongation of refractoriness and action potential duration.

Key Properties

• CAS Number: 101526-62-9
• MW: 349.87
• Purity: >98% (HPLC)
• Formula: C₁₄H₂₄ClN₃O₃S
• SMILES: CCN(CC)CCNC(=O)c1ccc(cc1)NS(=O)(=O)C.Cl
• Target: K+ current (IKr) channel
• Solubility: In Vitro: H2O : 5 mg/mL (14.29 mM)

Bioactivity

• In Vivo:
  Sematilide (0.3-1.0 mg/kg, intravenously i. v.) is effective in a canine model of arrhythmia. Animal model: Mongrel dogs of either sex (10-18 kg body weight). Dosage: 0.3, 1, 3, and 10 mg/kg. Administration: I. v. infusions. Result: Demonstrated antiarrhythmic effects at 0.3 and 3.0 mg/kg.
• In Vitro:
  Application of 10, 30, 100 and 300 μM Sematilide causes a concentration-dependent inhibition of the delayed rectifier K+ current (IC50 = 25 μM).

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

K+ current (IKr) channel