Selpercatinib

SKU: orb1299110

Description

Selpercatinib (LOXO-292) is a selective RET kinase inhibitor, demonstrating potent activity against wild-type RET (IC50 14.0 nM) and mutant variants. It is widely used in preclinical research for investigating RET-driven cancers, with applications in both in vitro cellular assays and in vivo tumor models.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 2152628-33-4
• MW: 525.6
• Purity: >99.99% (May vary between batches)
• Formula: C₂₉H₃₁N₇O₃
• SMILES: COc1ccc(CN2C3CC2CN(C3)c2ccc(cn2)-c2cc(OCC(C)(C)O)cn3ncc(C#N)c23)cn1
• Target: c-RET
• Solubility: DMSO:7 mg/mL (13.32 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.9 mM)

Bioactivity

• Target IC50:
  RET (V804M):24.1 nM |RET (G810R):530.7 nM|RET (WT):14.0 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Selpercatinib, RET, RET (G810R), RET (V804M), RET (WT), anticancer, cRET, FVB/NRj mice, Inhibitor, inhibit, LOXO 292, LOXO292, LOXO-292

Compound Identifiers

PubChem CID

134436906