SD-06

SKU: orb1225459

Description

SD-06 is a p38 MAP kinase inhibitor, inhibits p38α with IC50 of 170 nM and inhibits LPS-stimulated TNF-release in rats ((83% inhibition at 1mg/kg, po).

Key Properties

• CAS Number: 271576-80-8
• MW: 397.8581
• Purity: >98% (HPLC)
• Formula: C₂₀H₂₀ClN₅O₂
• SMILES: OCC(N1CCC(C2=C(C3=NC=NC=C3)C(C4=CC=C(Cl)C=C4)=NN2)CC1)=O
• Target: p38 MAPK
• Solubility: DMSO: ≥ 29 mg/mL

Bioactivity

• In Vivo:
  SD 0006 (0-30 mg/kg) may be an effective alternative to steroids and biologics for RA therapy. SD0006 (3.75, 7.5 and 15 mg/kg; p.o. ; b. i. d.) is highly effective in attenuating SCW-induced inflammation as shown by the dose-dependent inhibition of paw swelling. Animal model: 8-to 12-week-old DBA/1 mice. Dosage: 3.75, 7.5 and 15 mg/kg. Administration: Orally twice daily. Result: Inhibited the transcription of several inflammatory mediators to prevent joint swelling and bone destruction and to preserve bone density.
• In Vitro:
  SD 0006 clearly inhibits p38α as shown by the dose-dependent inhibition of phosphorylation of its endogenous Hsp27 substrate.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SD 06 | SD06

Quick Database Links

Gene Symbol

p38 MAPK