SB 297006

SKU: orb1221566

Description

SB 297006 is an antagonist of C-C chemokine receptor 3 (CCR3; IC50 = 39 nM), which normally is activated by eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1δ. It is at least 250-fold selective for CCR3 over a panel of other chemokine receptors. SB 297006 blocks CCR3-mediated calcium mobilization induced by eotaxin, eotaxin-2, and MCP-4 in transfected cells. It suppresses antigen-induced accumulation of Th2 lymphocytes and eosinophils in lungs of mice when delivered subcutaneously (100 mg/kg).

Key Properties

• CAS Number: 58816-69-6
• MW: 342.4
• Purity: >98% (HPLC)
• Formula: C₁₈H₁₈N₂O₅
• SMILES: O=[N+]([O-])c2ccc(C[C@H](NC(=O)c1ccccc1)C(=O)OCC)cc2
• Target: CCR
• Solubility: DMSO : 150 mg/mL 438.15 mM;H2O : < 0.1 mg/mL

Bioactivity

• In Vitro:
  SB297006 is a CCR3 antagonist, significantly inhibits proliferation and neurosphere formation in CCL11-treated neural progenitor cells (NPCs) at 100 μM.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

CCR