SB297006

SKU: orb1302665

Description

SB297006 is a potent and selective CCR3 antagonist (IC50 = 39 nM) that inhibits chemokine-induced calcium flux in vitro. It has demonstrated efficacy in vivo by reducing antigen-driven pulmonary recruitment of Th2 cells and eosinophils in mouse models, supporting its use in research on allergic inflammation and asthma.

Research Area

Immunology & Inflammation, Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 58816-69-6
• MW: 342.35
• Purity: 99.65% (May vary between batches)
• Formula: C₁₈H₁₈N₂O₅
• SMILES: CCOC(=O)[C@H](Cc1ccc(cc1)[N+]([O-])=O)NC(=O)c1ccccc1
• Target: CCR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (11.68 mM);H2O:< 0.1 mg/mL (insoluble);DMSO:150 mg/mL (438.15 mM)

Bioactivity

• Target IC50:
  CCR3:39 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SB 297006, SB297006, SB-297006, inhibit, Inhibitor, CC chemokine receptor, CCR3, CCR

Compound Identifiers

PubChem CID

9840971