SAR131675

SKU: orb1301153

Description

SAR131675 is a selective small molecule inhibitor of VEGFR3 (FLT4) with a reported IC50 of 23 nM. It is a valuable research tool for studying lymphangiogenesis in both cellular assays and animal models, particularly in oncology and vascular biology research.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 1433953-83-3
• MW: 358.39
• Purity: 99.74%
• Formula: C₁₈H₂₂N₄O₄
• SMILES: C(C)N1C=2C(C(=O)C(C(NC)=O)=C1N)=CC=C(C#C[C@@](COC)(C)O)N2
• Target: VEGFR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.58 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:70 mg/mL (195.32 mM)

Bioactivity

• Target IC50:
  VEGFR3:23 nM

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, Vascular endothelial growth factor receptor, VEGFR3, VEGFR, SAR 131675, SAR131675, SAR-131675

Compound Identifiers

PubChem CID

71295845