SAR131675 (b)

SKU: orb1222879

Description

SAR131675 is a potent and selective VEGFR-3 inhibitor. It inhibited VEGFR-3 tyrosine kinase activity and VEGFR-3 autophosphorylation in HEK cells with IC(50) values of 20 and 45 nmol/L, respectively. SAR131675 was found to be highly selective for VEGFR-3 versus 107 receptors, enzymes, ion channels, and 65 kinases. SAR131675 is the first highly specific VEGFR-3-TK inhibitor described to date, displaying significant antitumoral and antimetastatic activities in vivo through inhibition of lymphangiogenesis and TAM invasion.

Key Properties

• CAS Number: 1092539-44-0
• MW: 358.16
• Purity: >98% (HPLC)
• Formula: C₁₈H₂₂N₄O₄
• SMILES: CCn1c(c(c(=O)c2c1nc(cc2)C#CC(C)(COC)O)C(=O)NC)N
• Target: VEGFR3

Bioactivity

• In Vitro:
  SAR131675 is a potent and selective VEGFR3 inhibitor with an IC50 of 23 nM.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SAR131675 | SAR 131675 | SAR-131675

Quick Database Links

Gene Symbol

VEGFR3