S-methyl-KE-298

SKU: orb1302990

Description

S-methyl-KE-298 is a primary plasma metabolite of KE-298, formed via methylation of deacetyl-KE-298. Its parent compound, KE-298, suppresses MMP-1 production in rheumatoid arthritis synovial cells, indicating its research application in studying RA pathology and metalloproteinase inhibition in vitro.

Research Area

Metabolism Research, Protein Biochemistry

Key Properties

• CAS Number: 143584-75-2
• MW: 252.33
• Purity: 97.33% (May vary between batches)
• Formula: C₁₃H₁₆O₃S
• SMILES: C(CC(CSC)C(O)=O)(=O)C1=CC=C(C)C=C1
• Target: Drug Metabolite,MMP
• Solubility: DMSO:100 mg/mL (396.31 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (15.85 mM)

Bioactivity

• In Vitro:
  In vitro protein binding of S-methyl-KE-298 is high in rat (>97%), dog (>89%) and human plasma (>99%), respectively.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, Matrix metalloproteinases, inhibit, M-2, M 2, MMP-1, MMP, DrugMetabolite, Drug Metabolite, S-methyl-KE 298, SmethylKE298, S-methyl-KE298, S-methyl-KE-298, S methyl KE 298

Compound Identifiers

PubChem CID

10037864