S-methyl-KE-298

SKU: orb1219257

Description

S-methyl-KE-298 is the second main metabolite in plasma,is a methyl conjugate of deacetyl-KE-298.KE-298 inhibits matrix metalloproteinase (MMP-1) production from rheumatoid arthritis (RA) synovial cells.

Key Properties

• CAS Number: 143584-75-2
• MW: 252.33
• Purity: >98% (HPLC)
• Formula: C₁₃H₁₆O₃S
• SMILES: CSCC(C(O)=O)CC(C1=CC=C(C)C=C1)=O
• Target: MMP
• Solubility: In Vitro: DMSO : 100 mg/mL (396.31 mM)

Bioactivity

• In Vitro:
  S-methyl-KE-298 is a methyl conjugate of deacetyl-KE-298 is plasma. In vitro protein binding of KE-298 and its plasma metabolites, deacetyl-KE-298 (M-1) and S-methyl-KE-298 (M-2), is high in rat (> 97%), dog (> 89%) and human plasma (> 99%), respectively. KE-298 blocks this IL-1β-induced pro-MMP-2 activation and MT1-MMP expression, but does not affect IL-1β-induced tissue inhibitor of metalloproteinase-2 (TIMP-2) secretion from rheumatoid synovial cells. KE-298 inhibits MMP-1 production fromrheumatoid arthritis (RA) synovial cells by affecting a transcription factor, AP-1. KE-298 inhibits the basal levels of MT1-MMP expression of unstimulated rheumatoid synovial cells.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

MMP