RS-25344 hydrochloride

SKU: orb1305685

Description

RS 25344 hydrochloride is a selective phosphodiesterase 4 (PDE4) inhibitor used in biochemical research. It is applied in vitro and in vivo to study PDE4's role in inflammatory pathways, making it relevant for investigations into diseases like asthma and COPD.

Research Area

Metabolism Research

Key Properties

• CAS Number: 152815-28-6
• MW: 411.8
• Purity: 99.58%
• Formula: C₁₉H₁₄ClN₅O₄
• SMILES: Cl.[O-][N+](=O)c1cccc(c1)-n1c2ncccc2c(=O)n(Cc2ccncc2)c1=O
• Target: PDE
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.86 mM);H2O:< 20.59 mg/mL;DMSO:50 mg/mL (121.42 mM)

Bioactivity

• Target IC50:
  PDE1:>100 μM (IC50)|PDE3:330 μM (IC50)|PDE2:160 μM (IC50)|PDE4:0.28 nM (IC50)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

phosphodiesterase, Phosphodiesterase (PDE), phosphodiesterase 4, RS 25344, RS 25344 hydrochloride, RS 25344 Hydrochloride, RS25344, RS-25344, RS25344 hydrochloride, RS25344 Hydrochloride, RS-25344 Hydrochloride, anti-inflammatory, antineoplastic, cAMP, cognition, lymphocytes, inhibit, human, memory, Inhibitor

Compound Identifiers

PubChem CID

19781728