RS 25344 hydrochloride

SKU: orb1218754

Description

RS 25344 hydrochloride is a phosphodiesterase (PDE) 4 inhibitor.

Key Properties

• CAS Number: 152815-28-6
• MW: 411.8
• Purity: >98% (HPLC)
• Formula: C₁₉H₁₄ClN₅O₄
• SMILES: O=C1N(C2=CC=CC([N+]([O-])=O)=C2)C3=NC=CC=C3C(N1CC4=CC=NC=C4)=O.[H]Cl
• Target: PDE
• Solubility: DMSO:80mg/ml(194.27mM; need ultrasonic)

Bioactivity

• In Vivo:
  RS-25344 hydrochloride (5 mg/kg; i.p.; twice daily for 72 h) results in significant increases in stomach weights in wild type C57BL/6 mice. RS-25344 hydrochloride (1 mg/kg; i.p.; 30 min prior to food bolus) increases gastric retention in mice.
• In Vitro:
  RS-25344 hydrochloride (0-10 μM) is a potent inhibitor of sperm PDE activity, with an effective concentration of 0.3 nM and reaching maximum inhibition in the range of 100 nM.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PDE