ROS-generating?agent?1

SKU: orb2900434

Description

ROS-generating agent 1 (Compound 2c) covalently modifies the Sec-498 residue of TrxR to generate ROS. ROS-generating agent 1 reduces intracellular TrxR protein level. ROS-generating agent 1 results in ROS-dependent apoptosis and ferroptosis of NCI-H460 cells. ROS-generating agent 1 has anti-cancer activities.

Key Properties

• CAS Number: 2369030-41-9
• MW: 411.34
• Purity: >98% (HPLC)
• Formula: C₂₁H₁₅F₆NO
• SMILES: C(=C\1/C(=O)\C(=C\C2=CC(C(F)(F)F)=CC=C2)\CNC1)\C3=CC(C(F)(F)F)=CC=C3
• Target: Ferroptosis
• Solubility: In Vitro: DMSO : 33.33 mg/mL (81.03 mM; Ultrasonic )

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Ferroptosis