ROS-generating agent 1

SKU: orb1944719

Description

This small molecule induces cancer cell death by covalently targeting the Sec-498 residue of thioredoxin reductase (TrxR), inhibiting its activity and depleting its protein levels. The consequent ROS generation triggers both apoptosis and ferroptosis, as demonstrated in studies using NCI-H460 non-small cell lung cancer cells.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 2369030-41-9
• MW: 411.34
• Purity: 99.76% (May vary between batches)
• Formula: C₂₁H₁₅F₆NO
• SMILES: C(=C\1/C(=O)\C(=C\C2=CC(C(F)(F)F)=CC=C2)\CNC1)\C3=CC(C(F)(F)F)=CC=C3
• Target: Reactive Oxygen Species,ROS Kinase,ROS,Ferroptosis,Apoptosis
• Solubility: DMSO:45 mg/mL (109.4 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ferroptosis, Apoptosis, ROSgenerating agent 1, ROS-generating agent 1, ROS Kinase, ROSKinase, ROS1

Compound Identifiers

PubChem CID

168429727