Risperidone

SKU: orb1310697

Description

Risperidone is an atypical antipsychotic that functions as a selective antagonist of dopamine D2 and serotonin 5-HT2 receptors. It is widely used in research to investigate neurotransmitter systems and antipsychotic mechanisms in both in vitro binding assays and in vivo behavioral models.

Research Area

Neuroscience

Key Properties

• CAS Number: 106266-06-2
• MW: 410.48
• Purity: >98%
• Formula: C₂₃H₂₇FN₄O₂
• SMILES: CC1=C(CCN2CCC(CC2)C2=NOC3=CC(F)=CC=C23)C(=O)N2CCCCC2=N1
• Target: Monoamine receptor
• Solubility: DMSO:4.11 mg/mL (10.01 mM);Ethanol:4.11 mg/mL (10.01 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.44 mM)

Bioactivity

• Target IC50:
  D2 receptor:3.57 nM(Ki)|α2C-adrenoceptor:1.3 nM(Ki)|5-HT2A:0.17 nM(Ki)|D3 receptor:3.6 nM(Ki)|D2L receptor:4.16 nM(Ki)
• In Vivo:
  In activated microglia, Risperidone significantly inhibits the production of NO and pro-inflammatory cytokines. In Caco-2 cells, Risperidone (1-50 mM) notably enhances the intracellular accumulation of Rh123 by inhibiting the activity of P-gp, with an IC50 value of 5.87 mM.
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• In Vitro:
  In rats, Risperidone (0.5 mg/kg) results in diminished weight gain and enhanced UCP1 gene expression in BAT, along with elevated serum prolactin levels. At a dose of (0.05 mg/kg), Risperidone increases food intake and leptin gene expression in white adipose tissue without affecting the rate of weight gain.
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Storage & Handling

• Storage: RT
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

P-glycoprotein, P-gp (P-glycoprotein), Pgp, P-gp, R 64 766, Serotonin Receptor, Risperidal, Risperidone, α2C-adrenergic receptor, D3, D2L, D2, DopamineReceptor, Dopamine, Dopamine Receptor, CD243, Cluster of differentiation 243, 5-hydroxytryptamine Receptor, 5HT Receptor, 5HTReceptor, Adrenergic Receptor, AdrenergicReceptor, 5-HT2A, 5-HT Receptor, ABCB1, inhibit, Multidrug resistance protein 1, MDR1, Inhibitor

Compound Identifiers

PubChem CID

5073