Risperidone

SKU: orb1310697

Description

Risperidone

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 106266-06-2
• MW: 410.48
• Purity: >99.99%
• Formula: C₂₃H₂₇FN₄O₂
• SMILES: CC1=C(CCN2CCC(CC2)C2=NOC3=CC(F)=CC=C23)C(=O)N2CCCCC2=N1
• Target: P-gp,Adrenergic Receptor,5-HT Receptor,Dopamine Receptor
• Solubility: DMSO:4.11 mg/mL (10.01 mM);Ethanol:4.11 mg/mL (10.01 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.44 mM)

Bioactivity

• Target IC50:
  D2 receptor:3.57 nM(Ki)|α2C-adrenoceptor:1.3 nM(Ki)|5-HT2A:0.17 nM(Ki)|D3 receptor:3.6 nM(Ki)|D2L receptor:4.16 nM(Ki)
• In Vivo:
  In activated microglia, Risperidone significantly inhibits the production of NO and pro-inflammatory cytokines. In Caco-2 cells, Risperidone (1-50 mM) notably enhances the intracellular accumulation of Rh123 by inhibiting the activity of P-gp, with an IC50 value of 5.87 mM.
• In Vitro:
  In rats, Risperidone (0.5 mg/kg) results in diminished weight gain and enhanced UCP1 gene expression in BAT, along with elevated serum prolactin levels. At a dose of (0.05 mg/kg), Risperidone increases food intake and leptin gene expression in white adipose tissue without affecting the rate of weight gain.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

P-glycoprotein, P-gp (P-glycoprotein), Pgp, P-gp, R 64 766, Serotonin Receptor, Risperidal, Risperidone, α2C-adrenergic receptor, D3, D2L, D2, DopamineReceptor, Dopamine, Dopamine Receptor, CD243, Cluster of differentiation 243, 5-hydroxytryptamine Receptor, 5HT Receptor, 5HTReceptor, Adrenergic Receptor, AdrenergicReceptor, 5-HT2A, 5-HT Receptor, ABCB1, inhibit, Multidrug resistance protein 1, MDR1, Inhibitor

Compound Identifiers

PubChem CID

5073