Paliperidone

SKU: orb1310964

Description

Paliperidone (9-hydroxyrisperidone), the primary active metabolite of risperidone, is an atypical antipsychotic indicated for acute and maintenance treatment of schizophrenia. It is widely used in pharmacological research for in vitro receptor binding studies and in vivo models to investigate its antipsychotic mechanisms and metabolic profile.

Research Area

Immunology & Inflammation, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 144598-75-4
• MW: 426.48
• Purity: 99.08%
• Formula: C₂₃H₂₇FN₄O₃
• SMILES: FC=1C=C2C(C(=NO2)C3CCN(CCC=4C(=O)N5C(=NC4C)C(O)CCC5)CC3)=CC1
• Target: 5-HT Receptor,Dopamine Receptor,Adrenergic Receptor,Histamine Receptor,Drug Metabolite
• Solubility: DMSO:4.3 mg/mL (10.08 mM)

Bioactivity

• In Vitro:
  Paliperidone significantly increases the intracellular accumulation of Rh123 and DOX in a concentration-dependent manner. Paliperidone works finely at low concentrations (10 and 50 μM) against Aβ(25-35) and MPP(+) and solely protects SH-SY5Y from hydrogen peroxide. Paliperidone (100 μM) completely diminishes cell reduction induced by different stressors, regardless of their dosages. Paliperidone is demonstrated with higher oxidative stress-scavenging properties than other APDs in several aspects, such as generated bulk glutathione, low HNE, and protein carbonyl productions. Paliperidone enhances dopamine toxicity at the highest dose and is the only AP that significantly increases cell viability (8.1%) compared with cells treated with dopamine alone.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

metabolite, Paliperidone, inhibit, Histamine Receptor, HistamineReceptor, Inhibitor, H1 receptor, AdrenergicReceptor, Adrenergic Receptor, 5-HT Receptor, 9-hydroxyrisperidone, 5-hydroxytryptamine Receptor, 5HTReceptor, 5-HT, 5HT Receptor, antipsychotic, atypical, Beta Receptor, Dopamine, Dopamine Receptor, DopamineReceptor, schizophrenia, β-adrenergic receptor, Serotonin Receptor

Compound Identifiers

PubChem CID

115237