Paliperidone

SKU: orb1310964

Description

Paliperidone (9-hydroxyrisperidone), the primary active metabolite of risperidone, is an atypical antipsychotic indicated for acute and maintenance treatment of schizophrenia. It is widely used in pharmacological research for in vitro receptor binding studies and in vivo models to investigate its antipsychotic mechanisms and metabolic profile.

Research Area

Neuroscience

Key Properties

• CAS Number: 144598-75-4
• MW: 426.48
• Purity: >98%
• Formula: C₂₃H₂₇FN₄O₃
• SMILES: FC=1C=C2C(C(=NO2)C3CCN(CCC=4C(=O)N5C(=NC4C)C(O)CCC5)CC3)=CC1
• Target: Monoamine receptor
• Solubility: Soluble in DMSO (up to 4 mg/ml)

Bioactivity

• In Vitro:
  Paliperidone significantly increases the intracellular accumulation of Rh123 and DOX in a concentration-dependent manner. Paliperidone works finely at low concentrations (10 and 50 μM) against Aβ(25-35) and MPP(+) and solely protects SH-SY5Y from hydrogen peroxide. Paliperidone (100 μM) completely diminishes cell reduction induced by different stressors, regardless of their dosages. Paliperidone is demonstrated with higher oxidative stress-scavenging properties than other APDs in several aspects, such as generated bulk glutathione, low HNE, and protein carbonyl productions. Paliperidone enhances dopamine toxicity at the highest dose and is the only AP that significantly increases cell viability (8.1%) compared with cells treated with dopamine alone.

Storage & Handling

• Storage: RT
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Paliperidone; 9-hydroxyrisperidone

Compound Identifiers

PubChem CID

115237