Rezafungin

SKU: orb1309158

Description

Rezafungin (SP-3025) is a long-acting echinocandin antifungal agent with broad-spectrum activity against pathogens including Candida and Aspergillus. It is utilized in research for both in vitro susceptibility testing and in vivo models of invasive fungal infections.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 1396640-59-7
• MW: 1226.39
• Purity: 99.87% (May vary between batches)
• Formula: C₆₃H₈₅N₈O₁₇
• SMILES: O=C1N2[C@](C(=O)N[C@H](OCC[N+](C)(C)C)[C@H](O)C[C@H](NC(=O)C3=CC=C(C=C3)C4=CC=C(C=C4)C5=CC=C(OCCCCC)C=C5)C(=O)N[C@@]([C@@H](C)O)(C(=O)N6[C@](C(=O)N[C@@]([C@@H]([C@@H](O)C7=CC=C(O)C=C7)O)(C(=O)N[C@]1([C@@H](C)O)[H])[H])(C[C@@H](O)C6)[H])[H])([C@@H](O)[C@@H](C)C2)[H]
• Target: Antifungal
• Solubility: DMSO:65 mg/mL (53 mM)

Bioactivity

• Target IC50:
  C. kefyr:0.06 µg/mL (MIC)|C. tropicalis:0.03 µg/mL (MIC)|C. insconspicua:0.06 µg/mL (MIC)|C. guilliermondii:1 µg/mL (MIC)|C. pulcherrima:0.03 µg/mL (MIC)|C. dubliniensis:0.06 µg/mL (MIC)|C. albicans:0.022 µg/mL (MIC)|C. lusitaniae:0.12 µg/mL (MIC)|C. glabrata:0.044 µg/mL (MIC)|C. krusei:0.033 µg/Ml (MIC)|C. auris:0.153 µg/mL (MIC)|C. parapsilosis sensu stricto:1.26 µg/mL (MIC)
• In Vivo:
  Intraperitoneal injection of 1 mg/kg of Rezafungin once daily for 6 days in mice showed effective in vivo prevention of Pneumocystis spp., significantly reducing nuclear and asci burden in a C3H/HeN mouse infection model.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Rezafungin, SP 3025, SP3025, SP-3025, infection, long-lasting, inhibit, Inhibitor, echinocandin, Fungal, glucan synthase, CD101, CD-101, CD 101, Biafungin, antifungal

Compound Identifiers

PubChem CID

78318119