Rebamipide

SKU: orb1223708

Description

Rebamipide, an amino acid derivative of 2-(1H)-quinolinone, is used for mucosal protection, healing of gastroduodenal ulcers, and treatment of gastritis. It works by enhancing mucosal defense, scavenging free radicals, and temporarily activating genes encoding cyclooxygenase-2.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 90098-04-7
• MW: 370.79
• Purity: >98% (HPLC)
• Formula: C₁₉H₁₅ClN₂O₄
• SMILES: O=C(O)C(NC(C1=CC=C(Cl)C=C1)=O)CC2=CC(NC3=C2C=CC=C3)=O
• Target: Free radical scavengers
• Solubility: DMSO: 74 mg/mL (199.57 mM)

Bioactivity

• In Vivo:
  Animal model: Specific pathogen-free male Sprague-Dawley rats (200-230 g; 7-week-old). Dosage: 5, 15, 50 mg/kg. Administration: Oral administration; once daily for 14 days. Result: Increased the level of COX-2 immunoreactivity and PGE2 in a dose-dependent manner. (PGE2 is implicated in protection of gastric mucosa from various insults and acceleration of gastric wound healing). Inhibited intragastric HCl administration-induced gastric mucosal bleeding and erosion.
• In Vitro:
  Cell Proliferation Assay Cell line: AGS cells. Concentration: 1.4, 2.7, 5.4 mM Incubation time: 24 h. Result: Significant decreased in cell proliferation in a concentration-dependent manner. Western blot analysis. Cell line: AGS cells. Concentration: 5.4 mM Incubation time: 30 min or 3 h. Result: Significantly increased phosphorylation of Smad2/3 by 1.2-fold when at 30 min and formation of Smad2/3-Smad4 complex by 1.4-fold. Upregulated expression of p21 protein by 2.5-fold when at 3 h.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

OPC 12759

Quick Database Links

Gene Symbol

Free radical scavengers