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Raphin1

SKU: orb1299476

Description

Raphin1 is a selective, orally active small molecule inhibitor targeting the phosphatase PPP1R15B (R15B). This tool compound enables research into integrated stress response pathways and has demonstrated utility in both cellular assays and animal models for studying conditions like protein misfolding diseases.

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number2022961-17-5
MW231.08
Purity>99.99% (May vary between batches)
FormulaC8H8Cl2N4
SMILESNC(=N)N\N=C\c1cccc(Cl)c1Cl
TargetPhosphatase
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (17.31 mM);DMSO:125 mg/mL (540.94 mM)

Bioactivity

Target IC50
R15B-PP1c holophosphatase:Kd:33 nM

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Inhibitor, inhibit, Raphin 1, Raphin-1, Raphin1, Phosphatase

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Quality Guarantee

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Key Properties

No computed properties available.

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Raphin1 (orb1299476)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 ml x 10 mM (in DMSO)
$ 70.00
5 mg
$ 70.00
10 mg
$ 90.00
25 mg
$ 130.00
50 mg
$ 170.00
100 mg
$ 230.00
200 mg
$ 320.00
DispatchUsually dispatched within 3-5 working days
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