Racecadotril

SKU: orb1223952

Description

Racecadotril, also known as acetorphan, is an antidiarrheal drug which acts as a peripherally acting enkephalinase inhibitor.(In Vivo):In mice, following i.v. administration, Racecadotril is rapidly metabolized to Thiorphan; thus, 30 min after the injection only Thiorphan is recovered from the kidney whereas the parent compound Racecadotril is not detected.In rats 92% of a single-dose (10 mg/kg) of radioactively labeled Racecadotril is eliminated within 24 h.Racecadotril is a neutral endopeptidase (NEP) inhibitor with known antidiarrheal activity in animals. Orally administered Racecadotril (100 mg/kg ) shows efficacy in a rat model of castor oil-induced diarrhea.

Key Properties

• CAS Number: 81110-73-8
• MW: 385.49
• Purity: >98% (HPLC)
• Formula: C₂₁H₂₃NO₄S
• SMILES: CC(=O)SCC(CC1=CC=CC=C1)C(=O)NCC(=O)OCC1=CC=CC=C1
• Target: Proteasome
• Solubility: DMSO: 22mg/ml(57.07 mM);Water: <1mg/ml;Ethanol: 77mg/ml(199.75 mM)

Bioactivity

• In Vivo:
  In mice, following i. v. administration, Racecadotril is rapidly metabolized to Thiorphan; thus, 30 min after the injection only Thiorphan is recovered from the kidney whereas the parent compound Racecadotril is not detected. In rats 92% of a single-dose (10 mg/kg) of radioactively labeled Racecadotril is eliminated within 24 h. Racecadotril is a neutral endopeptidase (NEP) inhibitor with known antidiarrheal activity in animals. Orally administered Racecadotril (100 mg/kg) shows efficacy in a rat model of castor oil-induced diarrhea. Animal model: 6-to-7-week-old male Wistar rats. Dosage: 100 mg/kg. Administration: A single oral treatment; 30 minutes before castor oil administration. Result: Significantly reduced stool output but did not prevent the occurrence of diarrhea (100% incidence).

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Acetorphan

Quick Database Links

Gene Symbol

Proteasome