Rabbit anti Human fibonectin

• Catalog Number: orb21229
• Category: Antibodies
• Description: Precipitating polyclonal rabbit antiserum to human fibronectin. Fibronectin is a glycoprotein with a molecular weight of 440,000 and consists of two identical peptide chains. Its mean concentration in plasma is 330 mg/ml. Elevated plasma levels of fibronectin are observed in chronic active liver disease; decreased values are found in cases of acute leukaemia, sepsis, severe burns, acute pancreatitis, inflammatory processes, haemorrhagic shock and polytrauma. Fibronectin is also present on cell surfaces. It cab be cross-linked to the fibrin clot by the action of F XIIIA. As formation of the clot occurs approximately 50% of the plasma Fibronectin is lost. Freund's complete adjuvant is used in the first step of the immunization procedure.
• Species/Host: Rabbit
• Clonality: Polyclonal
• Antibody Type: Primary Antibody
• Form/Appearance: Delipidated, heat inactivated, lyophilized, stable whole antiserum. Sodium azide 0.7 mg/ml Total protein and IgG concentrations in the antiserum are comparable to those of normal pooled rabbit serum. No foreign proteins added.
• Conjugation: Unconjugated
• Hazard Information: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This product contains sodium azide. To prevent formation of toxic vapors, do not mix with strong acidic solutions. To prevent formation of potentially explosive metallic azides in metal plumbing, always wash into drain with copious quantities of water. This datasheet is as accurate as reasonably achievable, but Biorbyt accepts no liability for any inaccuracies or omissions in this information.
• UniProt ID: P02751
• Source: Fibrinogen (clotting factor I) is a heat labile beta glycoprotein (molecular weight 340,000) and consists of three pairs of chains bound by disulphide bonds. It is synthesized in hepatocytes under genetic control. It is the precursor of fibrin, which is the key protein constituting the network of the blood clot. Thrombin converts fibrinogen to fibrin by limited proteolysis, releasing the fibrinopeptides A and B (molecular weight 50,000-65,000) and forming fibrin monomers. Fibrin monomers polymerize to fibrin which is stabilized by cross-linking under the influence of factor XIII. The predominant gamma chain of normal fibrinogen (MW 50,000, with higher variants) has a low affinity for platelet binding. Fibrinogen is isolated from fresh plasma after removing prothrombin. Freund’s complete adjuvant is used in the first step of the immunization procedure.
• RRID: AB_10751439
• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Buffer/Preservatives: Delipidated, heat inactivated, lyophilized, stable whole antiserum. Sodium azide 0.7 mg/ml Total protein and IgG concentrations in the antiserum are comparable to those of normal pooled rabbit serum. No foreign proteins added.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.