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QX77

SKU: orb1302672

Description

QX77 is a small molecule activator of chaperone-mediated autophagy (CMA). It is used in research to study CMA's role in cellular proteostasis, aging, and neurodegenerative diseases, with applications in both in vitro and in vivo experimental models.

Research Area

Cell Biology

Images & Validation

Key Properties

CAS Number1798331-92-6
MW300.74
Purity98.38%
FormulaC16H13ClN2O2
SMILESCC(=O)Nc1ccc(cc1)C1=Nc2ccc(Cl)cc2OC1
TargetAutophagy
SolubilityDMSO:17.5 mg/mL (58.19 mM)

Bioactivity

In Vitro
Treatment with CMA activator QX77 rescues Rab11 down-regulation and trafficking deficiency in cystinotic cells. QX77 treatment also increases LAMP2A localization at the lysosomal membrane.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

QX77, QX-77, QX 77, Rab11, inhibit, pluripotency, Inhibitor, MEFs, LAMP2A, CMA, Autophagy

Similar Products

  • QX77 [orb1222596]

    >98% (HPLC)

    1798331-92-6

    300.74

    C16H13ClN2O2

    1 g, 500 mg, 200 mg, 5 mg, 10 mg, 50 mg, 100 mg, 25 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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Protocol Information

QX77 (orb1302672)

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% DMSO +
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% Tween 80 +
%

Available Sizes

Select a size below

2 mg
$ 70.00
5 mg
$ 90.00
10 mg
$ 120.00
25 mg
$ 190.00
50 mg
$ 290.00
100 mg
$ 440.00
200 mg
$ 620.00
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