Quinine sulfate dihydrate

SKU: orb2900228

Description

Quinine sulfate hydrate (2:1:4) is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine sulfate hydrate (2:1:4) is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM.

Key Properties

• CAS Number: 6119-70-6
• MW: 818.97
• Purity: >98% (HPLC)
• Formula: C₄₀H₅₈N₄O₁₂S
• SMILES: O.O.OS(O)(=O)=O.[H][C@@]12CCN(C[C@@H]1C=C)[C@@]([H])(C2)[C@H](O)c1ccnc2ccc(OC)cc12.[H][C@@]12CCN(C[C@@H]1C=C)[C@@]([H])(C2)[C@H](O)c1ccnc2ccc(OC)cc12
• Target: Potassium Channel

Bioactivity

• In Vivo:
  Quinine sulfate hydrate (oral gavage, 12 or 15 mg/kg, every week, 16 weeks) has some tumor suppressing effect on skin cancer in Swiss albino mice. Quinine sulfate hydrate (oral gavage, 10 mg/kg, everyday, 8 weeks) causes a decrease in the antioxidant defense system of rat testicular tissue such as SOD, CAT and GSH enzyme activity in male adult albino rats. Animal model: Swiss albino mice 7-8-weeks (weighing 24 g). Dosage: 12 mg/kg, 15 mg/kg. Administration: Oral gavage; every week; 16 weeks. Result: Resulted in a significant reduction in tumor size and weight at 12 mg/kg and little effect at higher dose of 15 mg/kg.
• In Vitro:
  Quinine sulfate hydrate (150 μM, 30 min) inhibits the proliferation and cytostatic effects of DENV (Dengue virus) in human hepatocarcinoma HepG2 cell line. Quinine sulfate hydrate (37.5-150 μM, 24 hours) significantly reduces viral DENV RNA and protein levels in a dose-dependent manner in human hepatocarcinoma HepG2 cell line. Cell Proliferation Assay Cell line: Human hepatocarcinoma cell line(HepG2). Concentration: 150 μM. Incubation time: 30 min. Result: Inhibited DENV virus replication with 19% yield compared to untreated. Reduced DENV-positive cells from 23.28% to 12.05% in a dose-dependent manner.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Potassium Channel