Quinine sulfate dihydrate

SKU: orb1741477

Description

Quinine sulfate dihydrate is a potassium channel blocker with antimalarial properties, widely used to study hemozoin metabolism and heme toxicity in malaria research. It also serves as a tool compound in cardiovascular and metabolic studies, applicable in both in vitro and in vivo experimental models.

Research Area

Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 6119-70-6
• MW: 818.97
• Purity: 99.99% (May vary between batches)
• Formula: C₄₀H₅₈N₄O₁₂S
• SMILES: O.O.OS(O)(=O)=O.[H][C@@]12CCN(C[C@@H]1C=C)[C@@]([H])(C2)[C@H](O)c1ccnc2ccc(OC)cc12.[H][C@@]12CCN(C[C@@H]1C=C)[C@@]([H])(C2)[C@H](O)c1ccnc2ccc(OC)cc12
• Target: Others,Parasite,Anti-infection,Potassium Channel
• Solubility: DMSO:8.19 mg/mL (10 mM)

Bioactivity

• Target IC50:
  P. falciparum (60 Thai isolates):10 to 500 nM (MIC)
• In Vivo:
  In mice, quinine reduces P. berghei parasite load in the blood with a minimum effective dose (MED) of 150 mg/kg .
• In Vitro:
  Quinine is an alkaloid antimalarial agent that has MIC values ranging from 10 to 500 nM for 60 Thai isolates of P. falciparum. It inhibits hemozoin formation in purified trophozoites, leading to an increase in free heme, similar to the mechanism of action of chloroquine.

Storage & Handling

• Storage: keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Potassium Channel, Quinine sulfate Dihydrate, Quinine sulfate dihydrate, Quinine Sulfate, PotassiumChannel

Compound Identifiers

PubChem CID

16211610