(Pyr5,N-Me-Phe8,Sar9)-Substance P (5-11)

SKU: orb3053984

Description

[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is a Substance P analogue that has approximately the same effects as Substance P on neurokinin 1 receptor (NK1R) in rat brain, but with a much longer duration of action. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) also increases motor activity and induces recovery of addictive agent-seeking behavior in rats.

Key Properties

• CAS Number: 77128-69-9
• MW: 880.06
• Purity: >98% (HPLC)
• Formula: C₄₃H₆₁N₉O₉S
• Solubility: DMSO : ≥ 100 mg/mL (113.63 mM; )

Bioactivity

• In Vivo:
  Animal model: Male Sprague-Dawley rats (300-350 g). Dosage: 2 μg/side. Administration: Inject into the ventral tegmental area; single. Result: Selectively activated mesolimbic and mesocortical dopamine metabolism. Animal model: Male Wistar rats (300-350 g). Dosage: 0.5, 1.5, 3 μg/side. Administration: Inject into the ventral tegmental area; single. Result: Significantly increased locomotor activity when at 3 μg/side.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only