PSB-12062

SKU: orb1309213

Description

PSB-12062 is a potent and selective P2X4 receptor antagonist, exhibiting an IC50 of 1.38 µM against the human isoform. This small molecule is a valuable research tool for investigating the role of P2X4 in neuropathic pain and neuroinflammation in both in vitro and in vivo models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 55476-47-6
• MW: 337.39
• Purity: 99.97%
• Formula: C₁₉H₁₅NO₃S
• SMILES: Cc1ccc(cc1)S(=O)(=O)N1c2ccccc2Oc2ccccc12
• Target: P2X Receptor
• Solubility: DMSO:3.38 mg/mL (10.02 mM)

Bioactivity

• Target IC50:
  P2X4 (rat):92.8 nM |P2X4 (mouse):1.76 μM |P2X4 (human):1.38 μM
• In Vitro:
  PSB-12062 is a selective P2X4 antagonist that was equally potent in all three species (IC(50): 0.928-1.76 μM). The compounds showed an allosteric mechanism of action.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

P2XReceptor, P2XRs, P2X Receptor, P2X4, PSB 12062, PSB12062, PSB-12062, inhibit, N-(p-Methylphenylsulfonyl)phenoxazine, Inhibitor

Compound Identifiers

PubChem CID

2320735