PSB-12062

SKU: orb1219757

Description

PSB-12062 is a potent and selective antagonist of P2X4(IC50 of 1.38 μM for human P2X4). PSB-12062 is a selective P2X4 antagonist that was equally potent in all three species (IC(50): 0.928-1.76 μM). The compounds showed an allosteric mechanism of action.

Key Properties

• CAS Number: 55476-47-6
• MW: 337.39
• Purity: >98% (HPLC)
• Formula: C₁₉H₁₅NO₃S
• SMILES: Cc1ccc(cc1)S(=O)(=O)N1c2ccccc2Oc2ccccc12
• Target: P2 Receptor
• Solubility: DMSO:24 mg/mL (71.13mM; Need ultrasonic)

Bioactivity

• In Vitro:
  PSB-12062 shows similar potency in human, rat, and mouse species. PSB-12062 shows to be allosteric in nature with a 35-fold selectivity toward P2X4 versus P2X1, P2X2, P2X3, and P2X7. However, PSB-12062 is unable to completely block ATP-induced P2X4-mediated calcium influx even when used at high concentrations (>30 μM).

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

N-(p-Methylphenylsulfonyl)phenoxazine

Quick Database Links

Gene Symbol

P2 Receptor