PROTAC SMARCA2 degrader-32

SKU: orb2814492

Description

PROTAC SMARCA2 degrader-32 (Compound 27) potently degrades SMARCA2 with a DC50 of 1.3 nM and demonstrates anti-proliferative activity in NCI-H838 lung cancer cells (GI50 = 34 nM). This molecule serves as a valuable chemical probe for studying SMARCA2 biology and targeted protein degradation in oncology research, both in vitro and in vivo.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 3033586-50-1
• MW: 970.66
• Formula: C₅₄H₆₄ClN₉O₄S
• SMILES: CC1(C)C=2N(C=3C1=CC=C(C3)C4CCN(C[C@@H]5CC[C@H](CC5)C6=CN([C@H](C(=O)N7[C@H](C(N[C@@H](C)C8=CC=C(C=C8)C9=C(C)N=CS9)=O)C[C@@H](O)C7)C(C)(C)C)N=N6)CC4)C=%10C(C(=O)N2)=C(Cl)C=CC%10
• Target: PROTACs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172677408