PROTAC SMARCA2/4-degrader-32

SKU: orb2665162

Description

PROTAC SMARCA2/4-degrader-32 (I-446) is a potent, cell-permeable degrader of SMARCA2 and SMARCA4 proteins, demonstrating DC50 values below 100 nM and achieving over 90% degradation (Dmax) in A549 cells within 24 hours. This tool compound is valuable for in vitro studies exploring SWI/SNF complex function in oncology and targeted protein degradation research.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2568273-79-8
• MW: 1012.28
• Formula: C₅₄H₆₉N₁₃O₅S
• SMILES: NC1=C(N2CC3N(C(C2)CC3)C=4N=CC(=CN4)[C@@H]5CC[C@H](CC5)N6CCN(CC(N[C@H](C(=O)N7[C@H](C(NCC8=CC=C(C=C8)C9=C(C)N=CS9)=O)C[C@@H](O)C7)C(C)(C)C)=O)CC6)C=C(N=N1)C%10=C(O)C=CC=C%10
• Target: PROTACs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

155390858