PROTAC ER Degrader-2

SKU: orb1987805

Description

PROTAC ER Degrader-2 is a key synthetic intermediate for constructing PAC, an antibody-conjugatable molecule that combines ADC linker and PROTAC technologies. The resulting PAC demonstrates enhanced degradation of estrogen receptor-alpha (ERα) in research settings compared to the unconjugated PROTAC, supporting investigations into targeted protein degradation.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• MW: 1581.85
• Formula: C₈₉H₁₀₄N₁₂O₁₅
• SMILES: CC/C(C1=CC=CC=C1)=C(C2=CC=C(OCCN(C)C(COCCOCCNC(C3=CC=C(C(N4[C@@H](C)[C@H](NC([C@H](C)N(C(OC(C)(C)C)=O)C)=O)C(N(CC5=C(OC)C=CC6=C5C=CC=C6)C7=C4C=C(C#N)C=C7)=O)=O)C=C3)=O)=O)C=C2)\C8=CC=C(OCC9=CC=C(NC([C@@H](NC([C@H](C(C)C)N)=O)CCCNC(N)=O)=O)C=C9)C=C8
• Target: Estrogen Receptor/ERR,Others,PROTACs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

138454783