PROTAC EGFR degrader 4

SKU: orb1982870

Description

PROTAC EGFR degrader 4 potently induces degradation of mutant EGFR variants, including del19 and L858R/T790M, with low nanomolar DC50 values. It demonstrates strong anti-proliferative effects in corresponding NSCLC cell lines, and its mechanism is linked to autophagy, making it a valuable tool for targeted protein degradation research in oncology.

Research Area

Cardiovascular Research, Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2882845-50-1
• MW: 995.29
• Formula: C₅₅H₇₀N₁₂O₄S
• SMILES: Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCN2CCN(CC2)c2ccc(Nc3ncc4nc(Nc5ccccc5)n(C5CCCC5)c4n3)cc2)C(C)(C)C)cc1
• Target: Autophagy,Others,EGFR,PROTACs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

162647755