Procarbazine hydrochloride

SKU: orb1308490

Description

Procarbazine hydrochloride

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 366-70-1
• MW: 257.76
• Purity: 98.00%
• Formula: C₁₂H₁₉N₃O·HCl
• SMILES: c1(C(=O)NC(C)C)ccc(cc1)CNNC.Cl
• Target: DNA Alkylator/Crosslinker,DNA/RNA Synthesis
• Solubility: H2O:48 mg/mL (186.22 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.76 mM);DMSO:45 mg/mL (174.58 mM);Ethanol:22 mg/mL (85.35 mM)

Bioactivity

• In Vivo:
  Procarbazine causes significant decrease in testicular and epididymal weight and a drastic reduction in haploid cells and spermatogenic arrest, demonstrating variation amon the test golden hamster. Procarbazine produces a dose-dependent potentiation of MAO A in brown adipose tissue the elevation being more pronounced following monomethylhydrazine, with activity rising to 350% of that in control homogenates in rats. Procarbazine or monomethylhydrazine reduces metabolism of this amine by a similar degree as had been determined ex-vivo in blood vessel homogenates. Procarbazine is mutagenic, clastogenic and teratogenic in a wide range of test systems of varying complexity and a wide-spectrum carcinogen in rodents and monkeys, causing tumours o the haemopoietic system the mammary g an the lung an the nervous system. Procarbazine in vivo undergoes a complex series of metabolic Changes that result in the generation of a number of chemically Reactive species, including methylating agents and free radicals.
• In Vitro:
  Procarbazine plus Cu(II) induce piperidine-labile and formamidopyrimidine-DNA glycosylase-sensitive lesions a the 5'-ACG-3' sequence, complementary to a hotspot o the p53 gene, an the 5'-TG-3' sequence. Procarbazine causes DNA damage through non-enzymatic formation o the Cu(I)-hydroperoxo complex and methyl radicals. Procarbazine has a strong clastogenic effect in hematopoietic cells and is mutagenic in a variety organs after high dose treatment.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Crosslinker, DNASynthesis, DNA Synthesis, DNA Alkylator, DNA Alkylator/Crosslinker, DNAAlkylator, DNA/RNA Synthesis, anticancer activity, L1210, Hodgkin's disease, Inhibitor, inhibit, NSC-77213 HCl, Procarbazine, Procarbazine HCl, Procarbazine hydrochloride, Procarbazine Hydrochloride, RNA Synthesis, RNASynthesis

Compound Identifiers

PubChem CID

9703