Procarbazine hydrochloride

SKU: orb1225188

Description

Procarbazine hydrochloride (Matulane) is a hydrochloride salt form of procarbazine which is a polyfunctional alkylating compound used as an antineoplastic agent. Procarbazine is a cytostatic agent, meaning it strands cells midway through cell division, but it does not actively kill them. Procarbazine interferes with cells at a number of sites to prevent DNA and protein synthesis and mitosis. Procarbazine hydrochloride (Matulane) is used in the treatment of Hodgkin’s lymphoma and other malignant lymphomas including:- lymphosarcoma- reticulosarcoma- Brill-Symmers disease. Because procarbazine hydrochloride (Matulane) works differently to other anticancer agents,Procarbazine hydrochloride (Matulane) may be useful in the treatment of Ys that have not responded to other treatments.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 366-70-1
• MW: 257.76
• Purity: >98% (HPLC)
• Formula: C₁₂H₁₉N₃O·HCl
• SMILES: Cl.CNNCC1=CC=C(C=C1)C(=O)NC(C)C
• Target: DNA/RNA Synthesis
• Solubility: Ethanol: 52 mg/mL (201.73 mM); Water: 52 mg/mL (201.73 mM)

Bioactivity

• In Vivo:
  Animal model: Male muta mouse (7–8 weeks old). Dosage: 50 and 150 mg/kg. Administration: Intraperitoneal injection; 50 and 150 mg/kg; once daily; 5 days. Result: Increased the MN frequency appreciably, and observed micronucleus induction in the peripheral blood at 50 mg/kg.
• In Vitro:
  Cell Viability Assay Cell line: L1210 cells. Concentration: 5 and 20 nM. Incubation time: 1 hour. Result: Showed 99.3% and 99.9% survival of cells at 5 mM and 20 mM, respectively.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Indicarb | Matulane | Natulan | NSC 77213

Quick Database Links

Gene Symbol

DNA/RNA Synthesis