Prasugrel

SKU: orb1310811

Description

Prasugrel (CS-747) is a thienopyridine-class antiplatelet agent used to inhibit thrombosis in acute coronary syndromes and during percutaneous coronary intervention. Its active metabolite irreversibly antagonizes the P2Y12 ADP receptor, a mechanism validated in both in vitro platelet aggregation assays and in vivo preclinical models of arterial thrombosis.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 150322-43-3
• MW: 373.44
• Purity: 99.86%
• Formula: C₂₀H₂₀FNO₃S
• SMILES: C(C(=O)C1CC1)(N2CC3=C(CC2)SC(OC(C)=O)=C3)C4=C(F)C=CC=C4
• Target: P2Y Receptor
• Solubility: DMSO:45 mg/mL (120.5 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.36 mM)

Bioactivity

• Target IC50:
  Platelet:1.8 μM
• In Vivo:
  Prasugrel has a faster, higher and more reliable platelet aggregation inhibitory effect than clopidogrel and is metabolized in vivo to an active metabolite with selective P2Y(12) antagonistic activity.
• In Vitro:
  Prasugrel has a faster, higher and more reliable platelet aggregation inhibitory effect than clopidogrel and is metabolized in vivo to an active metabolite with selective P2Y(12) antagonistic activity.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

P2YReceptor, P2Y12, P2Y Receptor, P2Y, Prasugrel, platelet, CS 747, CS747, CS-747, antiplatelet, aggregation, ADP, active, inhibit, Inhibitor, LY 640315, LY640315, LY-640315, metabolite, PCR 4099, PCR4099, PCR-4099

Compound Identifiers

PubChem CID

6918456