Plx-4032

SKU: orb1298741

Description

Vemurafenib (PLX-4032) is a selective B-Raf kinase inhibitor used in research for malignant melanoma. It is widely applied in both in vitro and in vivo studies to investigate targeted therapies against cancers harboring the BRAF V600E mutation.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1029872-54-5
• MW: 489.92
• Purity: 99.36%
• Formula: C₂₃H₁₈ClF₂N₃O₃S
• SMILES: CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c1F
• Target: Raf
• Solubility: DMSO:30 mg/mL (61.23 mM)

Bioactivity

• In Vivo:
  PLX-4032 and its related analogs are highly potent inhibitors of B-Raf activity, with 3-fold selectivity for the V600E mutation over the wild-type kinase. In preclinical models, PLX-4032 and its analogs inhibited the growth of BRAFV600E-positive melanoma cell lines both in vitro and in vivo.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Vemurafenib, Plx 4032, Plx4032, Plx-4032, 18504-65-1, B-Raf

Compound Identifiers

PubChem CID

42611257