Piracetam

SKU: orb1310628

Description

Piracetam

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 7491-74-9
• MW: 142.16
• Purity: 99.72%
• Formula: C₆H₁₀N₂O₂
• SMILES: NC(=O)CN1CCCC1=O
• Target: iGluR,GluR
• Solubility: DMSO:50 mg/mL (351.72 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (14.07 mM);H2O:351.72 mM

Bioactivity

• In Vivo:
  Piracetam, when pre-incubated with lipopolysaccharides (at Piracetam to peptide ratios ranging from 9.6 to 960), can dose-dependently inhibit the peptide-induced release of calcein completely. It has been observed through the reduced anisotropy of the membrane-bound fluorescent probe 1,6-diphenyl-1,3,5-hexatriene (DPH) that Piracetam (< 1.0 mM) can enhance the membrane fluidity of brain cells in aged rats, mice, and humans. Piracetam significantly reduces the fusion and destabilizing effects of Abeta 29-42 in a concentration-dependent manner. Pre-incubating Piracetam with the peptide at a 960 ratio, 20 minutes before introducing Abeta 29-42, fully protected both types of fluorescent probes.
• In Vitro:
  Excluding the cerebellum, Piracetam enhances active avoidance learning in aged rats and increases membrane fluidity across all brain regions. A daily dose of 300 mg/kg Piracetam significantly boosts membrane fluidity in certain cerebral areas of aged rats without noticeable effects on juvenile rats. Six weeks of daily administration of 300 mg/kg Piracetam elevates NMDA receptor density in the hippocampus, as well as the density of muscarinic cholinergic receptors in the frontal cortex and striatum, with a slight increase also observed in the hippocampal region. Oral administration of 500 mg/kg Piracetam for 14 consecutive days increases NMDA receptor density by approximately 20% in aged mice and restores the normal affinity of L-glutamate for NMDA receptors. Compared to control and alcohol-fed rats, those treated with Piracetam show a 20% increase in synaptic numbers, suggesting a mechanism of synaptic reorganization at the level of mossy fiber synapses.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AMPA, iGluR, Inhibitor, inhibit, Ionotropic glutamate receptors, UCB6215, UCB-6215, UCB 6215, Piracetam

Compound Identifiers

PubChem CID

4843