Piperazine citrate

SKU: orb1307872

Description

Piperazine citrate is a heterocyclic organic compound featuring a six-membered ring with two opposing nitrogen atoms. It is widely used as an anthelmintic agent in research, with applications in parasitology for studying anti-parasitic mechanisms in both in vitro and in vivo models.

Research Area

Infectious Disease & Virology, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 144-29-6
• MW: 642.65
• Purity: 99.80% (May vary between batches)
• Formula: C₂₄H₄₆N₆O₁₄
• SMILES: C1CNCCN1.OC(=O)CC(O)(CC(O)=O)C(O)=O
• Target: GABA Receptor,Parasite
• Solubility: DMSO:2.5 mg/mL (3.89 mM)

Bioactivity

• In Vivo:
  Fifteen of 20 Wistar albino rats were treated with various doses of the anthelmintic agent piperazine citrate (15, 30, and 60 mg/kg body weight). All 20 rats were subsequently given barium chloride, 20 mg/kg. The 5 rats (25%) that did not receive piperazine citrate developed ventricular fibrillations after barium chloride was administered to them, via one of the external jugular veins, and died shortly thereafter. The remaining 75% of the rats were fully protected by all the doses of piperazine citrate employed for the study. Barium chloride did not produce any dysrhythmic phenomenon in the piperazine-protected rats. Conversely, sinus rhythm was maintained in the electrocardiogram of all the rats, with every P wave followed by a normal QRS-T complex.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Gamma-aminobutyric acid Receptor, GABAReceptor, GABA, GABA Receptor, Inhibitor, inhibit, 1,4-Diazacyclohexane, Piperazine, Piperazine citrate, Piperazine Citrate, γ-Aminobutyric acid Receptor

Compound Identifiers

PubChem CID

114763