Pimelic diphenylamide 106

SKU: orb1304440

Description

RGFA-8 (Pimelic diphenylamide 106) is a potent and selective slow, tight-binding inhibitor of Class I HDAC enzymes, demonstrating nanomolar IC50 values against HDAC1, 2, and 3. This compound is a valuable chemical probe for epigenetic research, facilitating the study of histone deacetylation in both cellular and biochemical assays.

Research Area

Epigenetics & Chromatin, Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 937039-45-7
• MW: 339.43
• Purity: 99.28% (May vary between batches)
• Formula: C₂₀H₂₅N₃O₂
• SMILES: Cc1ccc(NC(=O)CCCCCC(=O)Nc2ccccc2N)cc1
• Target: Monoamine Transporter,HDAC
• Solubility: DMSO:55 mg/mL (162.04 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:1 mg/mL (2.95 mM)

Bioactivity

• Target IC50:
  HDAC8:5000 nM|HDAC3:370 nM|HDAC1:150 nM|HDAC2:760 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, HDAC, Histone Deacetylase Inhibitor VII, Histone deacetylases, inhibit, RGFA 8, RGFA8, RGFA-8, TC-H 106, TC-H106, TC-H-106, Pimelic diphenylamide 106, Pimelic Diphenylamide106, Pimelic Diphenylamide-106

Compound Identifiers

PubChem CID

16070100