Phospho-Leptin Receptor (Tyr1141) Antibody

• Catalog Number: orb1730593
• Category: Antibodies
• Description: On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones (By similarity).
• Species/Host: Rabbit
• Clonality: Polyclonal
• Tested applications: ELISA, WB
• Reactivity: Human, Mouse
• Isotype: Rabbit IgG
• Immunogen: Synthetic peptide of human LEPR
• Dilution range: WB: 1/500-1/1000; ELISA: 1/10000
• Conjugation: Unconjugated
• MW: Calculated MW: 132 kDa; Observed MW: 132 kDa
• Entrez: 3953
• UniProt ID: P48357
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Buffer/Preservatives: Liquid in PBS containing 50% glycerol, 0.5% rAlbumin and 0.02% sodium azide, pH 7.3.
• Alternative names: Leptin receptor; LEP-R; HuB219 OB receptor; OB-R;
• Note: For research use only
• Expiration Date: 12 months from date of receipt.