Phenidone

SKU: orb1940400

Description

Phenidone is a dual inhibitor of cyclooxygenases and lipoxygenases that ameliorates rat paralysis in experimental autoimmune encephalomyelitis by suppressing its target enzymes. The lipoxygenase inhibitor phenidone is a potent hypotensive agent in the spontaneously hypertensive rat.(In Vitro):Western blot analysis showed that phenidone significantly inhibited the increases in COX-1/-2 and 5-LOX in the spinal cords of rats with EAE.(In Vivo):Lipoxygenase inhibitor phenidone markedly attenuates angiotensin II (AII) induced vascular contractility. Phenidone was also shown to inhibit the formation of vascular lipoxygenase products and to reduce blood pressure in the AII-dependent renovascular hypertensive rat.

Key Properties

• CAS Number: 92-43-3
• MW: 162.192
• Purity: >98% (HPLC)
• Formula: C₉H₁₀N₂O
• SMILES: OC1=NN(CC1)c1ccccc1
• Target: Lipoxygenase
• Solubility: In Vitro: DMSO : 100 mg/mL (616.56 mM)

Bioactivity

• In Vivo:
  Phenidone inhibits the formation of vascular lipoxygenase products and to reduce blood pressure in the AII-dependent renovascular hypertensive rat.
• In Vitro:
  Phenidone significantly inhibits the increases in COX-1/-2 and 5-LOX in the spinal cords of rats with experimental autoimmune encephalomyelitis (EAE).

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

1-phenyl-3-pyrazolidinone

Quick Database Links

Gene Symbol

Lipoxygenase