Phenacetin

SKU: orb1310301

Description

Phenacetin (Acetophenetidin) is a withdrawn analgesic phenylacetamide associated with nephrotoxicity and methemoglobinemia. It is now used in research as a reference compound in toxicology studies and for investigating the metabolism and mechanisms of analgesic-related adverse effects in experimental models.

Research Area

Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 62-44-2
• MW: 179.22
• Purity: 98.00% (May vary between batches)
• Formula: C₁₀H₁₃NO₂
• SMILES: N(C(C)=O)C1=CC=C(OCC)C=C1
• Target: COX
• Solubility: DMSO:60 mg/mL (334.78 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (11.16 mM);Ethanol:34 mg/mL (189.71 mM)

Bioactivity

• Target IC50:
  COX-3:102 μM (IC50)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cyclooxygenase, CYP1A2, COX, COX-1, COX-3, Acetophenetidin, analgesic, antipyretic, Inhibitor, inhibit, Phenacetin, probe

Compound Identifiers

PubChem CID

4754