Phenacetin

SKU: orb1224425

Description

Phenacetin is a non-opioid analgesic without anti-inflammatory properties. Its analgesic effects are due to its actions on the sensory tracts of the spinal cord. In addition, phenacetin has a depressant action on the heart, where it acts as a negative inotrope. Phenacetin is an antipyretic, acting on the brain to decrease the temperature set point. Phenacetin is also used to treat rheumatoid arthritis (subacute type) and intercostal neuralgia.(In Vitro):Phenacetin shows inhibitory activity for COX-3 with an IC50 value of 102 μM in insect cells .Phenacetin is a substrate widely used as an in vitro and in vivo probe to measure the activity of CYP1A2, because the metabolism of phenacetin to acetaminophen is thought to be a selective CYP1A2-mediated reaction.(In Vivo):Phenacetin exhibits elimination half-life (rat 2.06 h) and Cmax (6,728.3 μg/L) following oral administration (rat 20 mg/kg).

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 62-44-2
• MW: 179.22
• Purity: >98% (HPLC)
• Formula: C₁₀H₁₃NO₂
• SMILES: CC(NC1=CC=C(OCC)C=C1)=O
• Target: COX
• Solubility: Ethanol: 36 mg/mL (200.87 mM); DMSO: 36 mg/mL (200.87 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

p-Acetophenetidide | 4′-Ethoxyacetanilide | NSC 7651

Quick Database Links

Gene Symbol

COX