Penciclovir

SKU: orb1225114

Description

A guanosine analogue antiviral agent used for the treatment of various herpesvirus (HSV) infections; inhibits viral DNA polymerase and exhibits low toxicity and good selectivity.HSV Infection Approved(In Vitro):Penciclovir (0-100 μg/ml) shows anti-herpesvirus activity with EC50s of 0.5, 0.8, 2.4, 52, 100, 1.2, 1.6, 0.9, >100 μg/ml for HSV-1 (HFEM), HSV-2 (MS), VZV (Ellen), CMV (AD-169), BHV-1 (Oxford 1964), BHV-2 (New York 1), EHV-1(Quai Hals), FHV-1 (B927), SVV, respectively.Penciclovir (0-100 μg/ml) shows no-toxic to uninfected human cells.(In Vivo):Penciclovir (100 mg/kg; s.c.; daily for 5 days) preventes mortality in mouse.

Key Properties

• CAS Number: 39809-25-1
• MW: 253.2578
• Purity: >98% (HPLC)
• Formula: C₁₀H₁₅N₅O₃
• SMILES: C1=NC2=C(N1CCC(CO)CO)NC(=NC2=O)N
• Target: HSV
• Solubility: DMSO: ≥ 53 mg/mL

Bioactivity

• In Vivo:
  Penciclovir (100 mg/kg; s. c. ; daily for 5 days) preventes mortality in mouse. Animal model: Three-week-old female Balb/c mice. Dosage: 100 mg/kg. Administration: S. c. ; daily for 5 days. Result: Reduced virus titres in the respiratory organs of both w/t-and PR3-infected mice.
• In Vitro:
  Penciclovir (0-100 μg/ml) shows anti-herpesvirus activity with EC50s of 0.5, 0.8, 2.4, 52, 100, 1.2, 1.6, 0.9, >100 μg/ml for HSV-1 (HFEM), HSV-2 (MS), VZV (Ellen), CMV (AD-169), BHV-1 (Oxford 1964), BHV-2 (New York 1), EHV-1(Quai Hals), FHV-1 (B927), SVV, respectively. Penciclovir (0-100 μg/ml) shows no-toxic to uninfected human cells. Cell Cytotoxicity Assay Cell line: MRC-5, WISH, Flow 4000, Flow 12000, RPMI 2650, WI-38, WI-38 VA13, Hs68, HEp-2, RD, SCC-13, Primary cells. Concentration: 0-100 μg/ml. Incubation time: Result: Showed no-toxic with IC50s of >100, >100, 100, >100, 60, >100, >100, >100, >100, >100, >100, >100 for MRC-5, WISH, Flow 4000, Flow 12000, RPMI 2650, WI-38, WI-38 VA13, Hs68, HEp-2, RD, SCC-13, Primary cells, respectively.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

VSA-671 | BRL-39123

Quick Database Links

Gene Symbol

HSV