p-Ethynylphenylalanine

SKU: orb1710559

Description

p-Ethynylphenylalanine is a potent, selective, and reversible competitive inhibitor of tryptophan hydroxylase (TPH) with a Ki of 32.6 µM. It is a valuable research tool for studying serotonin biosynthesis in both cellular and animal models of related disorders.

Research Area

Metabolism Research

Key Properties

• CAS Number: 278605-15-5
• MW: 189.21
• Purity: 97.57% (May vary between batches)
• Formula: C₁₁H₁₁NO₂
• SMILES: N[C@@H](Cc1ccc(cc1)C#C)C(O)=O
• Target: Hydroxylase
• Solubility: DMSO:2 mg/mL (10.57 mM);1M HCl:216 mg/mL (1141.59 mM);1M NaOH:216 mg/mL (1141.59 mM)

Bioactivity

• Target IC50:
  TPH:ki:32.6 μM |TPH:32.6 μM (Ki)
• In Vivo:
  4-Ethynyl-L-phenylalanine (30 mg/kg; i.p.) decreases in 5-HT and 5-HIAA levels in the rat midbrain but not in tissue. It is not inhibiting the aromatic amino acid decarboxylase. It has a low affinity for various recombinant 5-HT receptors.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

4-Ethynyl-L-phenylalanine, p-Ethynylphenylalanine, Testosterone 6 beta-hydroxylase

Compound Identifiers

PubChem CID

25216972