p-Ethynylphenylalanine hydrochloride

SKU: orb1310047

Description

p-Ethynylphenylalanine hydrochloride

Research Area

Metabolism Research

Key Properties

• CAS Number: 188640-63-3
• MW: 225.67
• Purity: 99.03% (May vary between batches)
• Formula: C₁₁H₁₂ClNO₂
• SMILES: Cl.N[C@@H](Cc1ccc(cc1)C#C)C(O)=O
• Target: Hydroxylase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (14.62 mM);H2O:12 mg/mL (53.17 mM);DMSO:99 mg/mL (438.69 mM)

Bioactivity

• Target IC50:
  TPH:32.6 μM
• In Vivo:
  Administration of p-Ethynylphenylalanine hydrochloride (30 mg/kg) to rats produced a 95 +/- 5% decrease in TPH activity in brain homogenates and a concomitant decrease in serotonin and 5-hydroxyindole-3-acetic acid levels (85%) at 24 h after injection.
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• In Vitro:
  p-Ethynylphenylalanine hydrochloride was demonstrated to inhibit competitively and reversibly TPH in vitro (Ki = 32.6 +/- 6.2 microM vs. tryptophan).

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

5-HIAA, 5-HT, 4-Ethynyl-L-phenylalanine HCL, inhibit, Inhibitor, hydroxylase, serotonin, p-Ethynylphenylalanine, pEthynylphenylalanine hydrochloride, p-Ethynylphenylalanine Hydrochloride, p-Ethynylphenylalanine hydrochloride(278605-15-5 free base), p Ethynylphenylalanine hydrochloride, TPH, tryptophan, Tryptophan Hydroxylase, Tryptophan hydroxylase

Compound Identifiers

PubChem CID

127264445