Orotic acid

SKU: orb1224317

Description

Orotic acid (OA) is an intermediate in pyrimidine metabolism. Orotic acid(6-Carboxyuracil) is a heterocyclic compound and an acid.(In Vitro):Orotic acid is found in milk and dairy products, and it is converted to uridine for use in the pyrimidine salvage pathway predominantly in liver, kidney and erythrocytes.(In Vivo):Orotic acid is a marker for measurement of urea cycle disorders (UCDs), including ornithine transcarbamylase deficiency (OTCD).Orotic acid (1.0% addition to the diet; p.o. for 3-10 d) induces a development of fatty liver by day 7, and decreases purine/pyrimidine ratio of hepatic acid-soluble nucleotides by day 3.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 65-86-1
• MW: 156.1
• Purity: >98% (HPLC)
• Formula: C₅H₄N₂O₄
• SMILES: OC(=O)C1=CC(=O)NC(=O)N1
• Target: Dehydrogenase
• Solubility: DMSO: 2 mg/mL (12.81 mM)

Bioactivity

• In Vivo:
  Orotic acid is a marker for measurement of urea cycle disorders (UCDs), including ornithine transcarbamylase deficiency (OTCD). Orotic acid (1.0% addition to the diet; p.o. for 3-10 d) induces a development of fatty liver by day 7, and decreases purine/pyrimidine ratio of hepatic acid-soluble nucleotides by day 3.
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• In Vitro:
  Orotic acid is found in milk and dairy products, and it is converted to uridine for use in the pyrimidine salvage pathway predominantly in liver, kidney and erythrocytes.
  Read more...

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Dehydrogenase